Browsing by Subject "Heart failure"
Now showing items 1-3 of 3
-
EXPLORING AND MODELING CARDIAC HYPERTROPHY USING H9C2 VENTRICULAR CELLS EXPOSED TO ANGIOTENSIN-II OR LIPOPOLYSACCHARIDE FOR STUDYING HEME METABOLISM REGULATION
(2023-12-15)Background: Hypertrophy occurs in heart failure with preserved ejection fraction (HFpEF). The extracellular signal-regulated protein kinases (Erk1/2) and heme-regulated inhibitory kinase (HRIK) regulate protein synthesis ... -
Optogenetic Tachypacing-induced Heart Failure in Larval Zebrafish
(2023-07-25)Chronic tachypacing is commonly used in mammals to model heart failure (HF). Alternative methods of chronic tachypacing involving the use of light-activated ion channels (‘optogenetics’) have been explored in cultured heart ... -
THE ROLE OF HEME REGULATORY ENZYMES IN MYOCYTES UNDER STRESS
(2016-09-06)The heme metabolism pathway remains a novel therapeutic target for heart failure treatment. However, how heme is regulated in the failing heart remains to be understood. To investigate the molecular mechanisms underlying ...